MSG is the taste of glutamate, a naturally occurring protein. Glutamate is a major component of most natural protein foods such as meat, fish, milk, and vegetables like mushrooms, tomatoes, and cabbage.
In our bodies, glutamate is the most abundant free amino acid in the brain and functions as a neurotransmitter and as fuel for cells. It is also abundantly present in the human breast milk. Glutamate elicits the taste of umami in our mouth, which is the fifth basic taste we feel as a lingering, savoury flavour.
In 1908, Japanese scientist Dr. Kikunae Ikeda first described umami as a distinct savoury and brothy flavour found in certain foods and established that glutamate gave us the sense of umami. In the early 2000s, Indian-origin biologist Dr. Nirupa Chaudhari discovered the unique taste receptors for umami in our body, thus cementing Dr. Ikeda’s finding that umami is a basic taste.
The tongue has taste buds which are connected to our brain (umami has five types of taste buds or receptors). When food enters our mouth, glutamate compounds bind to their receptors and send signals to the brain, eliciting an umami or flavourful sensation. We get the lingering savoury and mouthfeel sensations of umami also because of the specialized umami receptors in our gastrointestinal tracts.